It is believed that this book directly inspired King Henry VIII to abandon his faith in Roman Catholicism, set up his own State Church, and confiscate the lands and property of said Church in his domain. Monks and nuns were persecuted and murdered as their property was stolen and put into the coffers of the Crown.

Henry's desire was not only for the gold and precious items of the Roman Catholic Church but also to divorce his current wife (he ended up having multiple wives and even had a few of them murdered), because he believed she was the reason he wasn't bearing a son for the throne. Tyndale could not bear this. He hated the Catholic Church and was happy to see it become destitute in his own land, but he could not have foreseen the long lasting effects of his reform in England. His attempt was to create a holy people of Britain, people who read God's Word and obeyed. He got this to a degree but also centuries of religious wars, bloodshed and vice all in the name of religious freedom. The doubt he inspired in the minds of faithful British Catholics (Luther did the equivalent in Germany) would have long lasting effects that reach down to our own day.

Today there are tens of thousands of Protestant sects all claiming allegiance to the Reformers' interpretations of the Bible. The license that the Reformers gave to Catholics to question the very highest religious authorities gave them the tools to question the Bible itself and also the governments under which they lived. The Reformation was to the religious world what the Renaissance was to the intellectual world. Things would never be the same again. Pandora's box was opened and it would never be closed again. Tyndale's English Reformation along with Luther's German and Zwingli's Swiss Reformation became convenient tools for the princes of Europe to rid themselves of the Pope's power and grab it for themselves. This unforeseen result in the formation of the modern world was assisted by this important historical work