CIA stringer Richard Lancaster has been tasked to search out drugs for the new MK-Meta Drug Program, a black ops program designed to use psychotropic drugs to disrupt international crime organizations in the US. On a routine trip to the Brazilian rain forest, Lancaster discovers a new, even stronger, and more dangerous variant of the potent borrachero tree, the source of what the Brazilians call burundanga, a scopolamine-like psychotropic powder.

The MK-Meta team decides to force a Yakuza tattoo artist, Takumi Endo, and his beautiful artist daughter, Michi, to dose the youngest son of a Yakuza Oyabun (Godfather) in order to steal a computer containing the accounting records of a rival gang. The attempt to steal the computer fails, resulting in the deaths of numerous innocent civilians, an event the newspapers call "The Massacre In Little Tokyo".

In order to cover up the disastrous plan, Lancaster kills Michi's father and any other witnesses associated with the failed scheme. Upon learning of her father's death, Michi is transformed from a peace-loving traditional Japanese daughter into a revenge-seeking vigilante in the form of a Japanese-style bosozoku, dubbed "The Black Crane". The Black Crane [Kurodzuru] bosozoku does not stop until all the people responsible for her father's death have been punished.