Best-selling author Ann Patchett and accomplished actor Hope Davis make a stellar combination for Patchett's latest novel, State of Wonder, an homage to Joseph Conrad's Heart of Darkness. Davis deftly voices an international cast of medical researchers in the Amazon jungle. Her talents enhance Patchett's artistically descriptive prose, in many cases coiling the jungle imagery closer than you may want.

Hope Davis voices Dr. Marina Singh's stoic professionalism as she, a pharmacologist, is sent to the Amazon jungle by her employer to seek information about the death of a colleague.

Patchett's gift is to give characters multiple, very human layers, and Davis' gift is to bring those creations to life. Dr. Singh's reserve falls apart as she is plagued by unsettling nightmares and vivid memories of past medical mistakes. Dr. Annick Swenson's imperious personality has, through Hope Davis, the ability to intimidate through your earbuds. Dr. Swenson's arrogance keeps everyone quaking until, as the story unfolds, Davis' tone allows hints of humanity to ease through the doctor's sharp-edged exterior. Davis easily moves from dialects as the individual personalities - among them, a West African doctor, an Indonesian researcher, and a self-absorbed Australian couple - flow one from the other. Davis gives a brilliant performance of a prickly, uncomfortable argument between the married couple Alan and Nancy Saturn, making all who are listening want to distract themselves with the scenery.

Terrain itself becomes if not a character, a force, in State of Wonder. Contrasting Dr. Singh's beloved Minnesota plains with the claustrophobic, crawling, itching, frighteningly enveloping jungle, Patchett's words offer Hope Davis another opportunity to shine artistically. Davis infuses Patchett's prose with palpable energy, allowing listeners to exult in the wide, open prairies of the Midwest and then sense the creeping terror of forbidding, dangerously alive Amazonian jungle. While Davis' depiction of a confrontation with an anaconda is not to be missed, be forewarned that Patchett's imagery and Davis' performance will put anyone listening right beside the panic-stricken fictional characters as a life-and-death battle ensues.

For fans of Ann Patchett, State of Wonder is all that one has been waiting for and more. The story has as many twists and turns as, well, the Amazon jungle itself. And Hope Davis takes the joy of a new Ann Patchett book to an even higher level of pleasure through her masterful performance. It is a fantastically compelling adventure trip without the hazards of incessant bug bites, poisonous critters, or sweltering heat. (Carole Chouinard)